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Users primarily interact with their computers by utilizing the software layer. This is because most user interactions, such as navigating the operating system, running applications, and managing files, occur through graphical user interfaces (GUIs) or command-line interfaces (CLIs) that are part of the software.

The software layer provides the tools and applications that enable users to perform tasks without needing to understand the underlying hardware or how the system works at a low level. This interaction is designed to be user-friendly, allowing individuals to accomplish their goals efficiently, such as browsing the internet, writing documents, or editing photos.

The other options involve interactions that are typically not performed directly by end users. For instance, using hardware interfaces is necessary for connecting devices but is not the primary means of interaction. Programming in low-level languages requires specialized knowledge and is generally done by developers rather than everyday users. Manipulating firmware directly is a complex activity that involves understanding the low-level functioning of hardware components, which most users do not engage in while using their computers.